Causes

Gangrene is caused by infection or ischemia, such as by the bacteria Clostridium perfringens[5] or by thrombosis (a blocked blood vessel). It is usually the result of critically insufficient blood supply (e.g., peripheral vascular disease) and is often associated with diabetes and long-term smoking. This condition is most common in the lower extremities. The best treatment for gangrene is revascularization (i.e., restoration of blood flow) of the affected organ, which can reverse some of the effects of necrosis and allow healing. Other treatments include debridement and surgical amputation. The method of treatment is, in general, determined depending on location of affected tissue and extent of tissue loss. Gangrene may appear as one effect of foot binding.